| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni
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| Autores: |
Galinier, Richard
Roger, Emmanuel
Mone, Yves
Duval, David
Portet, Anais
Pinaud, Silvain
Chaparro, Cristian
Grunau, Christoph
Genthon, Clemence
Dubois, Emeric
Rognon, Anne
Arancibia, Nathalie
Dejean, Bernard
Theron, Andre
Gourbal, Benjamin
Mitta, Guillaume
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| Data: |
2017-03
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| Ano: |
2017
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| Resumo: |
In recent decades, numerous studies have sought to better understand the mechanisms underlying the compatibility between Biomphalaria glabrata and Schistosoma mansoni. The developments of comparative transcriptomics, comparative genomics, interactomics and more targeted approaches have enabled researchers to identify a series of candidate genes. However, no molecular comparative work has yet been performed on multiple populations displaying different levels of compatibility. Here, we seek to fill this gap in the literature. We focused on B. glabrata FREPs and S. mansoni SmPoMucs, which were previously demonstrated to be involved in snail/schistosome compatibility. We studied the expression and polymorphisms of these factors in combinations of snail and schistosome isolates that display different levels of compatibility. We found that the polymorphism and expression levels of FREPs and SmPoMucs could be linked to the compatibility level of S. mansoni. These data and our complementary results obtained by RNA-seq of samples from various snail strains indicate that the mechanism of compatibility is much more complex than previously thought, and that it is likely to be highly variable within and between populations. This complexity must be taken into account if we hope to identify the molecular pathways that are most likely to be good targets for strategies aimed at blocking transmission of the parasite through the snail intermediate host.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00388/49951/50515.pdf
https://archimer.ifremer.fr/doc/00388/49951/50516.pdf
https://archimer.ifremer.fr/doc/00388/49951/50517.xls
https://archimer.ifremer.fr/doc/00388/49951/50518.xlsx
https://archimer.ifremer.fr/doc/00388/49951/50519.xlsx
https://archimer.ifremer.fr/doc/00388/49951/50520.xlsx
DOI:10.1371/journal.pntd.0005398
https://archimer.ifremer.fr/doc/00388/49951/
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| Editor: |
Public Library Science
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| Formato: |
application/pdf
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| Fonte: |
Plos Neglected Tropical Diseases (1935-2735) (Public Library Science), 2017-03 , Vol. 11 , N. 3 , P. e0005398 (1-25)
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| Direitos: |
2017 Galinier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
info:eu-repo/semantics/openAccess
restricted use
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